Category Archives: Premarin Horses

Side effects of raising awareness about the Premarin family of drugs and PMU horses

There have been significant side effects to the work we are doing on behalf of the horses affected by the making of the Premarin family of drugs — Premarin (cream and tablet), Prempro, Premphase and Duavee.

BILLBOARD

Remember our billboard campaign? It’s a simple one. It says, “Warning: Premarin Contains Horse Urine”.

We placed these warning billboards near women’s hospitals. Horse lovers leafleted and talked to thousands of women and medical staff about the making of Premarin and how it impacts the lives of the pregnant mares it uses and what happens to so many of their foals.

Staff from these medical centers began telling our volunteers how Premarin is used in ways other than for the treatment of menopausal symptoms. It is a long list but here are two such examples:

Premarin is given to patients prior to and post hysterectomy surgery. Another example is using Premarin in conjunction with surgical procedures for patients who are deemed at risk of hemorrhaging — Premarin clots the blood.

There are many more. We will cover that soon in a separate post. If you have encountered any please let us know.

Social media advocates contributed too. You helped by sharing our post about our billboard. It reached well beyond the 10K+ notification for Facebook alone.

See https://tuesdayshorse.wordpress.com/2014/03/06/reach-thousands-save-thousands-with-premarin-billboards/

Image from PMU farm in Manitoba showing the collection bag used to collect the urine from pregnant mares used in the making of the Premarin family of drugs.
Image from PMU farm in Manitoba showing the collection bag used to collect the urine from pregnant mares used in the making of the Premarin family of drugs.

DEAR DOCTOR LETTER

Our Dear Doctor Letter has done more than just alert the medical personnel we sent it to. It has helped in all sorts of unforeseen ways.

For instance, we had physicians and even their family members contacting us telling us we were giving out misinformation concerning Premarin. They said that Premarin contained conjugated estrogens that were not dangerous. We stated that Premarin is made with conjugated equine estrogens – which are listed by the World Health Organization as known carcinogens – and the FDA allowed the producers of the Premarin family of drugs to omit the word “equine” some years ago.

A number of these doctors (or their relatives who called us to defend them) flat out refused to believe us, or so they said. Surely it’s not a big leap to see where the makers of these drugs got the name Premarin (Pregnant Mare’s Urine).

One doctor who at last acknowledged that the Premarin family of drugs are made with conjugated equine estrogens with the use of pregnant mare’s urine blurted out at the moment of awareness, “that means contain carcinogens and we shouldn’t be prescribing them”. He then concluded for himsef that in his mind at least there is no doubt to why these drugs no longer have the word equine in the labeling.

So what do we do with this information? We lobby the FDA to change the labeling to accurately reflect the drugs’ true nature. That is the plan. It is a steep mountain to climb but we are willing to climb it. But we may not be alone and will have some very important help. More on that later.

To those of who have sent this letter and to all the volunteers who printed and sent thousands more, we thank you.

Please continue to send this letter to your doctors particularly OB/GYNs. Print and mail or email as an attachment.
https://tuesdayshorse.files.wordpress.com/2015/12/dear_physician_ltr_cee_drugs_jan_2016.pdf

TELEVISION AND PRINT ADS

Thanks to your reporting, we have contacted television stations across the country for more than a year regarding the airing of Premarin cream commercials. They have, except in a few stubborn cases, either removed them and/or refused to renew them. We have also had a major impact regarding magazine and newspaper ads — print and online — via Twitter and Facebook.

This campaign, like so many, relies on the help of horse lovers like you. Congratulations on a job well done. Please continue to let us know when you see any type of ad for these products. We have a contact form here on Tuesday’s Horse specifically for this purpose. It’s in the dropdown box under Contact Us entitled Report Premarin Ads.

Rescued Premarin Foals. Image Vivian Grant Farrell.
Rescued Premarin Foals. Image Vivian Grant Farrell.

OUR MISSION CONTINUES

Our mission to help Premarin – or PMU – horses continues. The impact of the work we do is sometimes not immediately seen, difficult to sum up or give exact figures for. But what we are doing is having an effect.

Our campaigns have been so innovative and effective other groups and individuals have followed in our footsteps. The horses need us all.

We must continue our efforts for without us these horses have no hope, no voice and will continue to be subjected to the cruelties and death associated with the making of the Premarin family of drugs.

QUOTE

“Nothing has been, or ever will be, appealing or beneficial about the PMU industry and the Premarin family of drugs; they are clearly harbingers of death from both sides of the equation”.
– JANE ALLIN

RELATED READING

Premarin — The Drugs, the Women, the Horses
Alternatives
Reports

PMU (pregnant mare’s urine) sector to expand

Sorry we have been so long posting this. We saw this the day it came out but 2016 started off unusually busy and hasn’t let up.

Looks like it’s more than Premarin tablets Pfizer are expecting women (and in some cases men) to swallow. Check this nonsense out. And the picture filed with it is even worse. They have pregnant mares outside grazing in high grass. But if you look closely you can see a foal too which means these horses have just given birth that’s why they are not “online”. We are talking about the “pee line”.

February 26, 2016

The Manitoba Cooperator reports:

    An expected increase in contracted volumes of pregnant mare urine over the next two years is a small bit of good news for Manitoba’s long-beleaguered PMU industry.

    Pfizer Canada says it will increase the amount of PMU collected from ranches in Manitoba and Saskatchewan during 2016 and 2017.

    Pfizer uses estrogen from PMU to manufacture Premarin used for hormone replacement therapy in post-menopausal women.

    Industry officials cautioned the announced increase in volume will probably not have a major impact on PMU production.

    “From our perspective, it’s not going to be anything of any significance,” said Norm Luba, executive director of the North American Equine Ranching Information Council, a non-profit association in Louisville, Kentucky representing PMU ranchers.

    “It will be a small increase over the current amount that we contract,” was all Christina Antoniou, corporate affairs manager for Pfizer Canada in Montreal, would say in an email message to the Manitoba Co-operator. “We are currently in the process of contracting for 2016-17 and therefore cannot provide any further details.”

    Antoniou indicated a recent improvement in Premarin sales is responsible for the increase.

Read it all here: http://www.manitobacooperator.ca/news-opinion/news/pmu-sector-to-expand/

These people are unbelievable. Literally. Pfizer are making more money than ever off the Premarin family of drugs. Even with price increases there is no way so few a number could possibly supply all the pregnant mare’s urine they need. Who are they kidding? Still, it is puzzle. What are they up to? We’ll let you know when we know.

There are some well informed comments to this article so Pfizer & Co are fooling no one.
.

Ty Savoy quotes this:

‘In fact if one person is unkind to an animal it is considered cruelty, but where a lot of people are unkind to a lot of animals, especially in the name of commerce, the cruelty is condoned and, once large sums of money are at stake, will be defended to the last by otherwise intelligent people.’

Ruth Harrison, Animal Machines: The New Factory Farming Industry (2013)

RELATED READING

https://tuesdayshorse.wordpress.com/category/march-for-premarin-horses/

FDA-Approved Alternatives to Premarin Derivatives – are they safer ?

by JANE ALLIN

Contrary to popular belief, the FDA has yet to approve any generic as a substitute for Premarin and its daughter products (i.e. Prempro, Premphase, Duavee).

Accordingly no prescription drugs used to treat menopausal symptoms, other than the Premarin family, contain pregnant mare’s urine.

Image from PMU farm in Manitoba showing the collection bag used to collect the urine from pregnant mares used in the making of the Premarin family of drugs.
Image from PMU farm in Manitoba showing the collection bag used to collect the urine from pregnant mares used in the making of the Premarin family of drugs.

However much confusion arises when the subject of HRT is broached, particularly in terms of the safety aspect of FDA-approved versions that are not derived from pregnant mare’s urine.

The vast majority of FDA-approved HRT prescription drugs are synthetic bioidenticals — hormones identical on a molecular level to endogenous hormones that are synthesized in the lab from natural plant sources.

These are not to be confused with the compounded bioidenticals, none of which are approved by the FDA.

Premarin and its derivatives are also synthetics but, of course, sourced from an animal by-product.

Apart from Brisdelle, the only non-hormonal FDA-approved HRT, the rest fall into three categories of hormone combinations as follows:

• Estrogen combinations (e.g. Estrace, Cenestin, Enjuvia, Menest)
• Estrogen/Progestin combinations (e.g. Activella)
• Estrogen/Androgen combinations (e.g. Menogen, Covaryx)

The estrogen combinations are intended as substitutes for Premarin and Duavee while the estrogen/progestin versions are proposed alternatives to Prempro and Premphase.

Estrogen/androgen replacement therapy primarily represents mainstay therapy for young women who have undergone a hysterectomy. See http://www.medscape.com/viewarticle/438357.

A good proportion of these drugs contain estradiol or esterified estrogens (non-equine) as the estrogen component (e.g. Estrace, Femtrace, Activella, Femhrt, Angeliq). However several have identical equine estrogens that are derived from plant-based sources versus pregnant mare’s urine.

That said, these drugs are not entirely identical nor are they exactly equivalent in constituents. Cenestin, Enjuvia, and Menest are three such HRTs included in this group.

Cenestin was originally developed as a generic for Premarin by Duramed/Barr but in 1997, the FDA refused to approve the abbreviated new drug applications from Duramed and Barr Laboratories for a generic version of Premarin.

The FDA’s rationale was quite straightforward. A synthetic generic version of Premarin could not be approved because the exact chemical composition of Premarin could not be fully identified. This has been a controversial topic for years, a topic The Horse Fund has visited in the past. See https://tuesdayshorse.wordpress.com/2014/11/14/the-quest-for-a-generic-premarin-a-bitter-pill-to-swallow/.

In any case, all three of these drugs – Cenestin, Enjuvia, and Menest – contain similar estrogen components that are found in Premarin and its derivatives.

Premarin however is a complex mixture of numerous hormonal components, of which only some of the estrogenic components are found in the plant-based synthetics.

The table below compares the ingredients of Premarin, Cenestin and Enjuvia. I was unable to locate the same information for Menest.

However the pharmacology is similar to the others and contains a mixture of esterified estrogenic substances, principally estrone, that are of the type excreted by pregnant mares (e.g. sodium estrone sulfate, sodium equilin sulfate).

ESTROGEN PREMARIN CENESTIN ENJUVIA
sodium estrone sulfate Yes Yes Yes
sodium equilin sulfate Yes Yes Yes
sodium 17 alpha-dihydroequilin sulfate Yes Yes Yes
sodium 17 beta-dihydroequilin sulfate Yes Yes Yes
sodium 17 alpha-betahydroequilenin sulfate Yes Yes Yes
sodium 17 beta-betahydroequilenin sulfate Yes Yes Yes
sodium 17 alpha-estradiol sulfate Yes Yes Yes
sodium equilenin sulfate Yes Yes Yes
sodium 17 beta-estradiol sulfate Yes Yes Yes
sodium D8,9-dehydroestrone sulfate Yes No Yes
5,7,9 (10) estratrien-3beta, 17 beta-diol Yes No No
17 alpha-dihydro-delta, 8,9-dehydroestrone Yes No No
17 beta-dihydro-delta, 8,9-dehydroestrone Yes No No
5,7,9 (10) estratrien-3betal-ol-17-one Yes No No
2-hydroxy-estrone Yes No No
2-methoxy-estrone Yes No No

In addition to the extra estrogens contained in Premarin, it also contains six progestin and four androgen equine hormones. See http://surmeno.blogspot.com/2006/03/comparison-of-ingredients-premarin-and.html.

Despite the fact that these alternatives contain several of the Premarin estrogenic components, a study comparing the pharmacokinetics and relative bioavailabilities of key estrogen components of Premarin with those of synthetic plant-based equivalents concluded that these are not in fact bioequivalent to Premarin and therefore cannot be assumed to be therapeutically equivalent. See http://www.ncbi.nlm.nih.gov/pubmed/10865186.

But does this mean that these and other FDA-approved synthetics are safe?

Unfortunately these alternative synthetics carry with them the same or similar warnings associated with their use.

However it is often cited in scientific literature that estrogens derived from pregnant mares urine pose a greater risk due to the complexity and concentrations of the combined hormones together with the unmistakable fact that equine estrogens are foreign to humans.

Given that alternatives such as Cenestin and Enjuvia assimilate the equine equivalents in Premarin, despite the fact they are derived from plants, it is perplexing why anyone would elect to choose these to alleviate menopausal symptoms – purely from the aspect of being equine-related and extrinsic to the human endocrine system. More likely it is a case where they are unaware of what they contain.

And what about the rest that contain estradiol (e.g. Estrace) and other esterified non-equine estrogens, or those that contain progestins and androgens extracted from plant sources?

Here are some examples of the risks associated with these so-called “safer” alternatives compared to the Premarin derivatives. Source: http://www.rxlist.com/script/main/hp.asp.

Estrogen-only HRT

Premarin (Conjugated Equine Estrogens – CEEs) http://www.rxlist.com/premarin-drug.htm
• Endometrial cancer, cardiovascular disorders, breast cancer and probable dementia (> 65 yrs).

Enjuvia (plant –derived equine estrogens) http://www.rxlist.com/enjuvia-drug.htm
• Endometrial cancer, cardiovascular disorders, breast cancer and probable dementia (> 65 yrs).

Estrace (estradiol – plant based) http://www.rxlist.com/estrace-drug.htm
• Endometrial cancer, cardiovascular disorders, breast cancer and probable dementia (> 65 yrs).

Estrogen –Progestin HRT

Prempro/Premphase (CEEs/progestin) http://www.rxlist.com/prempro-drug.htm
• Invasive breast cancer, cardiovascular disorders, and probable dementia (> 65 yrs).

Activella (estradiol/progesterone – plant based) http://www.rxlist.com/activella-drug.htm
• Invasive breast cancer, cardiovascular disorders, and probable dementia (> 65 yrs).

And let’s not forget the newest addition to the Premarin family.

Duavee (CEES/bazedozifene(SERM) http://www.rxlist.com/duavee-drug.htm
• Endometrial cancer, cardiovascular disorders, and probable dementia (> 65 yrs).
• The SERM bazedoxifene is believed to inhibit the formation of breast cancer cells by binding to the estrogen receptor thus interfering with its activity.

Premstoppers Campaign. Warning, Premarin Contains Horse Urine.

The picture is clear.

In effect the FDA-approved hormone-containing alternatives carry with them the same risks and warnings associated with drugs derived from conjugate estrogen estrogens, whether that be estrogen alone or combinations. Albeit the risks may not be of the same significance as those associated with drugs manufactured from pregnant mare’s urine.

Nonetheless they still exist, and potentially more so for susceptible individuals.

Although the hormonal ingredients are similar or equivalent, they may or may not function identically for any single given woman. This applies to the Premarin derivatives as well.

And so, as much as it may seem that these hormones are safer than the Premarin family of drugs, there is no solid evidence to prove this.

It is important to note that some of these drugs have been approved by the FDA because data collected from trials has proven their effectiveness in relieving menopausal symptoms and reducing the risk of osteoporosis.

However there have been no long-term studies like the WHI performed to assess their safety profile.

In the absence of comparable data, the risks are generally assumed to be similar to CEEs and other forms of estrogens.

Moreover, regardless of the source and type of hormones, it is always recommended that estrogens, with or without progestins, should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment.

Brisdelle as an alternative?

Brisdelle approved.
Brisdelle becomes first non-hormonal replacement therapy drug for the treatment of menopausal symptoms in NA.

As mentioned there is only one FDA-approved non-hormonal HRT. In early June of 2013 the U.S. Food and Drug Administration approved the drug “Brisdelle” (paroxetine – Paxil) manufactured by Noven Pharmaceuticals for the treatment of hot flashes due to menopause.
 
Brisdelle contains the selective serotonin reuptake inhibitor paroxetine mesylate, making it unique from all other FDA-approved treatment for hot flashes which contain the hormones estrogen or progestin. 

Brisdelle poses none of the risks associated with estrogens or estrogen combination therapies.

However it is a selective serotonin reuptake inhibitor (SSRIs) (antidepressant), which has been shown to increase the risk of suicidal thoughts and behavior in pediatric and young adult patients when used to treat major depressive disorder and other psychiatric disorders. See http://www.rxlist.com/brisdelle-drug.htm.

Whether this risk applies to menopausal women is unclear.

As with any drugs and medications there are inherent risks, the nature of which can range from mild to life-threatening. Always consult your doctor to help decide what is best for your particular situation.

Please visit our Alternatives to Premarin page to learn more about options other than drugs containing conjugated equine estrogens. See http://www.horsefund.org/pmu-alternatives-to-cee-drugs.php.

Comparing the cost of FDA-approved HRT

Pharmaceutical Industry: A prescription for money.
Pharmaceutical Industry: A prescription for making huge profits.

As an aside and for interest’s sake here is a list of some of the more common HRTs available and the costs associated with them. The list is by no means comprehensive and includes the tablet form of the drug only.

This information was taken from http://www.goodrx.com and pertains only to the U.S. Prices are per tablet and converted to monthly costs based on a 30-day interval.

For consistency, all of the costs were taken from Walgreen’s with the discount coupons applied. Obviously prices will vary depending on store, geographic location, available coupons, etc. and are only intended to provide a relative comparison using the same base source.

DRUG NAME TYPE GENERIC
AVAILABLE?
PATENT
EXPIRATION
DATE
PRICE
PER
TABLET
MONTHLY
COSTS
(APPROX)
Prempro / Premphase CEEs / Progestin No Expired $5.77 $173
Brisdelle SSRI (paroxetine) No Apr 2029 $5.74 $172
Duavee CEEs / SERM (bazedoxifene) No Oct 2016 $4.77 $143
Premarin CEEs No Expired $4.33 $130
Angeliq Estrogen / Progestin No Oct 2017 $4.31 $129
Cenestin CEEs — plant based No Expired $3.97 $119
Prefest Estradiol / Progestin No March 2020 $3.37 $112
Enjuvia CEEs — plant based No Feb 2021 $2.75 $83
Femtrace Estradiol acetate No Dec 2021 $2.68 $80
Activella Estradiol / Progestin Yes Expired $2.06 $78
Menest CEEs — plant based No Expired $1.77 $53
Femhrt Estrogen / Progestin Yes Expired $1.32 $40
Ogen Estrogen (estrone) Yes Expired $0.28 $8
Estrace Estradiol Yes Expired $0.13 $4

Clearly, Pfizer is laughing all the way to the bank at the expense of women and horses alike.

END.

© The Horse Fund

Print friendly version of this report (pdf, 7 pp)

Learn more the horses and drugs made from their urine at Premstoppers »

Help get horse pee ads off the air and out of magazines

Duavee ad, August 2014, Better Homes and Gardens.
August 2014, Better Homes and Gardens.

Ridiculous.

Menopause is not a disease. It is a natural change in hormones that takes place when women begin to move past their childbearing years.

Hot flashes may occur and make you uncomfortable during that time. Last I heard hot flashes caused by menopause most likely will never kill you.

Last class action lawsuit I saw demonstrates that drugs made with horse pee such as Premarin, Prempro, Premphase and its latest incarnation — DUAVEE — can cause cancer. The World Health Organization has been saying this for a long while. Drugs made with conjugated equine estrogens are known carcinogens.

Premarin Cream ads peddle the idea to menopausal woman that they are too dried up to enjoy sex. Really?

If women are old enough to have symptoms of menopause, surely they are old enough to know what lube is and how to use it.

SOUND THE ALERT!

Let us know when and where you see advertisements for Premarin, Premarin Cream, Duavee (or Duavive in the EU) by completing the form below.

If aired on television, we must know which show you were watching please and the time. When we contact television stations their staff do not want to look it up. Let’s make it as easy for them as we can so they will co-operate.

Here’s the form. Fill in the revelant bits. Click submit when you are ready. Your information will be sent directly to our inbox. Thank you!

CONTACT FORM


 

What are we doing with this information? We are getting these ads off the air and out of magazines by alerting advertisers to the nature of these products.

Oprah (I thought she had retired or something) ignores all requests and still advertising Premarin Cream. I guess she doesn’t care. And she’s a horse owner too.

FACEBOOK

Our Facebook page is active again. See https://www.facebook.com/HorseFund. Please feel free to post this information there.

LEARN MORE

— Learn more about the horses and foals who abused by this obnoxious industry at Premstoppers »