The checkered history of Pfizer’s Premarin family of drugs

The drugs The name Premarin® spells out in its name what it is made from — PREgant MAres uRINe. Pfizer's Premarin® family of hormone replacement therapy drugs of today includes not only Premarin®, but also similarly manufactured pharmaceuticals — marketed at various times — under the names Prempro®, Premphase®, Provera® and later Aprela® (originally called…

Tell doctors not to prescribe Premarin’s new sister drug Duavee

It is critical that we as horse advocates step up immediately and inform doctors about Duavee. Duavee (formerly called Aprela) is the recently FDA approved and newest member of the Premarin family of drugs for the treatment of menopausal symptoms. It is set to enter the market at the beginning of 2014. We are already…

Big Pharma wins again: FDA approves Aprela under new name

BY JANE ALLIN Despite government shutdown, on October 3, 2013 the FDA approved the dual-acting drug formerly known as Aprela for the treatment of menopausal symptoms and prevention of postmenopausal osteoporosis in women who have not undergone a hysterectomy.[1] It’s new name is fittingly ugly -- DUAVEE® -- for an ugly vile drug that robs…

And now a word from a PMU industry sponsor

Part 2 of a Special Report by Jane Allin There are those that continue to promote and defend the atrocities associated with the PMU industry -- those who profit from the exploitation of both women and horses alike. Enter the king of the horse pee industry – Norman Luba – Executive Director of NAERIC (North…

Aprela® — the making of a new pregnant mare’s urine drug

Part 1 of a Special Report by Jane Allin October 3, 2013 looms as the harbinger of foreboding news for PMU mares and their foals. This is the day that the U.S. Food and Drug Administration (FDA) will make a decision whether or not to approve Ligand Pharmaceutical’s dual-acting drug Aprela® for the treatment of…

FDA rejects possible Premarin replacement drugs

With concerns about risks associated with conventional hormone replacement therapy (HRT) manufactured from the urine of pregnant mares (i.e. Premarin®, Prempro®) Depomed Inc., a specialty pharmaceutical company headquartered in Newark, California, submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) on July 31, 2012 for Serada™ – an extended time…

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Pfizer pharms and Premarin generics: who’s tapping whose PMUs?

Makers of generic Premarin are looking to move in on Pfizer's contracted PMU ranchers In May Tuesday's Horse reported that the announced job cuts by Pfizer at their estrogen extraction plant in Manitoba is not expected to affect PMU ranchers in Canada and no closures are anticipated. Premarin® and Prempro® are made with the estrogen…

Pfizer consigns PMU horses to killing fields of Asia

"If anyone believes that the downsizing of the PMU industry here in North America is advantageous for the mares and foals who suffer at the hands of Big Pharma, they are sadly mistaken" -- Jane Allin The news in January 2009 of pharmaceutical giant Pfizer’s announcement to take over rival company Wyeth for $68 billion…

Int’l Fund for Horses calls on Pfizer to find alternative to Premarin like drugs

UPDATE. March 1, 2014. :: See Updated Letter to Pfizer The Int'l Fund for Horses call on pharmaceutical giant Pfizer to find an alternative to the Premarin family of drugs. Premarin, Prempro and the anticipated "new" drug Aprela, manufactured with the estrogen rich urine of pregnant mares, or conjugated equine estrogen. In a letter to…

Premarin and Prempro: The consequences of deception – A litany of litigation

Written by JANE ALLIN In early July of 2002 the alarming news of the National Institutes of Health Women’s Health Initiative (WHI) study sent shock waves through the medical and scientific communities. Wyeth’s hormone combination replacement therapies (e.g. Prempro®), long believed to provide cardiovascular benefits to the millions of menopausal women who took them, now…