Premarin Horses and China

The last PMU (pregnant mare’s urine) facility operating in N. America — in Canada — is reportedly closing down. This has been a long time coming.

However, while that sounds like good news, HRT (hormone replacement therapy) drugs made from pregnant mare’s urine is on the rise in China where millions of women are already taking forms of it.

China is also where most of the world’s pregnant mare’s urine farms are.

PMU Farm in Xinyuan County, China (2012).
PMU Farm in Xinyuan County, China (2012).

Pregnant mares are repeatedly impregnated and milked for their urine in revolting conditions. The foals are immediately disposed of, often sent to local restaurants to be turned into “fresh off the hoof” dishes. Or, like the mares who can no longer get pregnant, are sent straight to a slaughterhouse. There are no rescues we know of for these horses anywhere in China.

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We must educate the women of China about these drugs and where they come from. Sensitivity to animal cruelty is on the rise and trending big in all but the most remote areas of China.

We are excited to announce that we now have a strong set of enthusiastic volunteers in China to get the word out. And television has begun reporting what we are doing. We feel it is critical that we continue to build on what we have achieved.

Please make a donation today to help pay for ads, subway signs, billboards and other marketing materials, plus translations for the media.  Support this vital work in China, and help continue our outreach to women across America too.

Thank you so much!

THE HORSE FUND
and TUESDAY’S HORSE

Population of endangered wild horse species on the rise in NW China

Przewalski's horse with her foal. /VCG Photo
Przewalski’s horse with her foal. /VCG Photo

CGTN Press Release | May 28, 2019

The population of Przewalski’s horse, the world’s last surviving wild horse subspecies, is growing at a nature reserve in northwest China’s Gansu Province, with numbers estimated to reach 40 by the end of 2019 after the breeding season in May.

Two foals were born on May 17 and 22 respectively in Gansu Anxi Extreme-arid Desert National Nature Reserve, while many more mares are pregnant.

The Przewalski’s horses were reintroduced to the reserve’s semi-wild environment in 2005. Three breeding groups and one male group have been formed.

Since then, the fertility rate of breeding mares has been maintained at around 60 percent, with the survival rate reaching 85 percent.

The population of Przewalski’s horse increased from 19 in 2016 to 37 at the end of May, and is expected to exceed 40 by the end of 2019.

Przewalski’s horses historically lived on grasslands that are now part of Mongolia and China’s Xinjiang Uygur Autonomous Region.

The species came to the verge of extinction in the 1960s due to over-hunting and a deteriorating environment. Its entire global population now stands at less than 2,000.

(Cover image via VCG.)

Source https://news.cgtn.com/news/189503-2/index.html

Three things we are doing for Premarin horses

Rescued Premarin foals. Photo: Vivian Grant Farrell.
Rescued Premarin foals. Photo: Vivian Grant Farrell.

Here are three things we are doing for PMU — or Premarin — horses right now:

1. Lobbying the FDA with the help of a specialist firm to return the word “equine” on all Premarin type drugs so it reads “conjugated equine estrogens” the way it did, and should*.

2. Working in China with a massive social media campaign warning women against the dangers of the Premarin family of drugs. This is where most of the horses are and where the largest volume of Premarin type drugs are being used. 

3. Leafleting across the U.S. at women’s hospitals and clinics warning women about the dangers of the Premarin family of drugs and educating them on alternatives (expanding into Canada with your help).

This work is informative and necessary, and potentially life saving for women and the mares and foals used to make the drug then cast off.


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We are the only voices PMU horses have. When we remove the demand for these drugs we remove the demand for pregnant mare’s urine thereby freeing the horses.

Share this with the women in your life and anyone else who might be exposed to this drug.

Helpful Links

Alternatives to Premarin®.

Premstoppers campaign page at The Horse Fund website.

Donate to Premstoppers.

Thank you for your caring support of women and horses.


* A conjugated estrogen can be made from plants.

Premarin, doctors and conjugated equine estrogens

March for Premarin Horses featured image.
The Premarin family of HRT drugs is made from the urine of pregnant mares.

Updated: 1:50 pm

MORE and more doctors who prescribe Premarin® are arguing with us that the menopausal drug no longer contains conjugated equine estrogens derived from pregnant mare’s urine. Huh?

The idea doctors most often cite in support of this belief is what it says on the drugs’ packaging, that Premarin® is made from “conjugated estrogens” where it used to say “conjugated equine estrogens”. Removing the word equine is something Pfizer pressed the FDA to do shortly we believe after they merged with or acquired Wyeth pharamaceuticals, adding these drugs to their portfolio. The removal of the word equine is obviously having its desired effect.

Premarin sample package with words "conjugated estrogens". Google search result. Unattributed image.
Premarin sample package with words “conjugated estrogens”. Google search result. Unattributed image.

Well dear doctors. A quick check on the internet should assure you that the Premarin® family of drugs including Duavee (originally called Aprela) which we don’t hear much of, has and assuredly always will be made with CEE’s — conjugated equine estrogens.

Wikipedia

Conjugated estrogens (CEs), or conjugated equine estrogens (CEEs), sold under the brand name Premarin (a contraction of “pregnant mares’ urine”) among others, is an estrogen medication which is used in menopausal hormone therapy and for various other indications. Read more »

RxList

PREMARIN® (conjugated estrogens tablets, USP) for oral administration contains a mixture of conjugated estrogens purified from pregnant mares’ urine and consists of the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. Be sure to check out the side effects. They include endometrial cancer, cardiovascular disorders, breast cancer and probably dementia. Read more »

DrugBank

Conjugated Equine Estrogens (CEEs) are derived from the urine of pregnant mares and contain a blend of at least 10 estrogen derivatives. Marketed under the brand name Premarin, CEEs are the most frequently used form of conjugated estrogens.

All estrogen products mimic the effects of endogenous estrogens in the body which are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics.

Conjugated estrogens, or Conjugated Equine Estrogens (CEEs) are composed of a mixture of the water-soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids that are purified from pregnant horse urine. Available as the product Premarin (FDA), this combination of equine-derived estrogenic compounds is indicated for the following conditions: treatment of moderate to severe vasomotor symptoms and vulvovaginal atrophy associated with menopause; hypoestrogenism due to hypogonadism, castration or primary ovarian failure; palliation of metastatic breast cancer; palliation of advanced androgen-dependent carcinoma of the prostate; and for prevention of postmenopausal osteoporosis. Read more »

PubChem

Premarin is a pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate. Read more »

See also NCBI » See also MedScape for Black Box Warnings such as increased risk of invasive breast cancer »

We get the picture. Surely doctors will now too.

Take Action

Dear Doctor Letter

Print and mail this letter to your doctor.

• PREMARIN_Dear_Doctor_Letter_UPDATED_October_2018_WORD (pdf, 4 pp)

Send this letter whether you are male or female. Doctors are known to use Premarin® intervenously to prevent bleeding during surgery.  So you may be treated with Premarin® without even knowing it or giving your permission. More to come on that so stay tuned here.

In the meantime, share far and wide. Save the horses!

China

The biggest challenge outside of the US is educating the Chinese who produce more pregnant mare’s urine and prescribe it more than anyone else in the world according to a recent source in China. And the Chinese love horse meat. So the two — Premarin® and horse slaughter — continues to go hand in hand.

Premarin tables. If you look closely you can see a legend in Chinese. Google image.
Premarin tables. If you look closely you can see a legend in Chinese. Google image.
Chinese version of Premarin cream.
Chinese version of Premarin cream.

In the meantime, doctors in the US are still prescribing and using the Premarin® family drugs at an alarming rate and seemingly unaware of the history and multiple dangers associated with this despicable drug.


Nothing has been, or ever will be, appealing or beneficial about the PMU industry and the Premarin family of drugs; they are clearly harbingers of death from both sides of the equation”.
– JANE ALLIN


Related Reading

•  Update! Alternatives to drugs made with pregnant mare’s urine by Jane Allin »

A look at a PMU farm in China and its not all about Pfizer »

Premstoppers

Premstoppers  is a Horse Fund campaign to eliminate drugs made with pregnant mare’s urine and their decades old legacy of cruelty and death.

Learn more at the Horse Fund website »

Donate

Donate to Premstoppers »

Thank you!