We made the following response to a comment on our Premarin 2019 Timeline and thought it might be worthwhile sharing with everyone as a post. We have altered it slightly to make the content clearer for this format.
Working as the Int’l Fund for Horses we are launching a social media campaign in Chinese and English in China. We originally thought that might not work. How many mature Chinese women are on social media?
Then we found out that most Chinese females 40 and under have learned to read and write English. So that’s why we will send our social media messages in both English and Chinese. That will reach the younger women who have English who can alert their female elders; and the 40+ women who do not have English.
We are also lucky because we have been able to get images of some of the Chinese versions of Premarin type drugs. This will help enormously on social media such as Twitter which relies heavily on visuals to catch attention.
The hugely disappointing part is that it appears the Chinese were either given, or have stolen/recreated Pfizer’s “recipe” for Premarin drugs and are manufacturing it themselves. Those drugs will be harder to identify but we have contacts who are trying to help us with that too.
The side effects will eventually show up making women question the use of these drugs.
Additionally, we have a British contact living and working in Hong Kong who is creating dual language posters warning of the dangers of these drugs listing them in their various Chinese names. We will try them out on bus shelters and train station platforms to start with. We have always had good outreach numbers at these type locations in other countries.
If you have ideas to share, or would like to help especially on social media such as Twitter, please use our contact form to get in touch with us.
FDA denies Pfizer Petition asking for new method of assessing Premarin generics
The FDA has denied a citizen petition from Pfizer calling on the agency to use the company’s method for assessing sameness in generics for its estrogen drug Premarin (conjugated “equine” estrogens).
Pfizer had appealed to the FDA to force sponsors of generics for Premarin to use the “Pfizer method” for assessing sameness rather than the method recommended in FDA draft guidance.
Pfizer claimed that the FDA’s December 2014 draft guidance for establishing sameness is “fundamentally flawed”. Additionally claiming that not only does it lack a critical level of sensitivity on API (Active Pharmaceutical Ingredient) steroidal composition, but also it does not account for all classes of components in the API or the non-steroidal components.
They maintained that guidance should instead use the “Pfizer Method” that the company developed at the FDA’s request and with their input, which permits a determination of sameness between a proposed generic for the company’s drug Premarin and the reference drug based upon the mixture as a whole, while allowing a comparison across all categories of components making up the API.
Bijuva launched for moderate to severe hot flashes in menopause
TherapeuticsMD announced the launch of Bijuva (estradiol and progesterone) capsules for use in women with a uterus for the treatment of moderate to severe vasomotor symptoms (hot flashes) due to menopause. It initially received approval from the Food and Drug Administration (FDA) in October 2018.
Bijuva is the first bio-identical hormone therapy that combines estradiol and progesterone in a single capsule. Compared with synthetic hormone products, the estradiol and progesterone found in Bijuva are structurally identical to the hormones naturally circulating in the woman’s body.
Bijvua carries a Boxed Warning regarding cardiovascular disorders, breast cancer, endometrial cancer, and probable dementia. Breast tenderness, headache, vaginal bleeding, vaginal discharge, and pelvic pain were the most common adverse reactions associated with Bijuva.
PMU Ranchers feel pinch as cuts announced
Pfizer Canada’s cuts to pregnant mares’ urine production will force four Manitoba ranches and one Saskatchewan ranch out of the industry.
The reduction affects three ranches in southwestern Manitoba, one in the Interlake region of Manitoba, and one in Saskatchewan. Of those five, three producers raised registered Quarter horses, one bred purebred Percherons, and one raised sport horses.
Pfizer has initiated a review of its inventory management and determined they are able to satisfy market demand by working with fewer ranchers.
The latest reduction leaves 19 producers still involved in PMU production in Manitoba and Saskatchewan, with most ranches located in southwestern Manitoba, four each in south-central Manitoba and southeastern Saskatchewan and one in the Interlake.
Pfizer’s Wyeth loses bid to duck hormone-therapy lawsuit
Pfizer Inc’s Wyeth unit must face a class action alleging that the drugmaker misled California women by downplaying risks including breast cancer associated with its hormone-replacement therapy products, a federal judge has ruled.
U.S. District Judge John Houston in San Diego on Monday ruled the plaintiffs presented sufficient evidence for a jury to decide whether Wyeth’s alleged misrepresentations caused women to buy Prempro, Premarin and Premphase.
New Book — Flash Count Diary: Menopause and the Vindication of Natural Life, by Darcy Steinke
“What orcas can teach humans about menopause and matriarchs” — A new book argues for a sea change in the way our culture views older women.
Her research unearthed a long history of dubious “cures,” from transfusions of dog’s blood to vinegar sponge baths to putting a magnet in your underpants. All of which, she says, seem a little less strange once you realize that the most popular hormone replacement treatment, Premarin, is made from the urine of pregnant horses. Source: Crosscut »
Hormone therapy during menopause raises breast cancer risk for years, study finds
New analysis adds to the evidence that many women who take hormone therapy during menopause are more likely to develop breast cancer — and remain at higher risk of cancer for more than a decade after they stop taking the drugs.
The study, in the Lancet, looked at data from dozens of studies, including long-term data on more than 100,000 women who developed breast cancer after menopause. The longer women took the medicine, the more likely they were to develop breast cancer. Experts say the findings could shape how women and their health care providers decide how to manage symptoms of menopause.
For years, research has suggested a potential link between MHT and an increased risk of breast cancer. But there wasn’t much information on whether that risk persisted, or how it differed based on the type of MHT a woman took. So, an international group of researchers pulled together data from dozens of studies — published and unpublished — to examine the issue more closely.
The researchers found that compared with women who never used MHT, women who did had a significantly higher risk of developing invasive breast cancer. Also, the longer women used MHT, the greater their risk of breast cancer.
Premarin sales figures continue to decline
The Premarin family of hormone replacement products was the 11th best seller in 2018 at $832 million, a decline of 14.8 percent. Sales in the first six months of 2019 were $361 million, 10 percent less than in same period of 2018.
Third quarter sales of Premarin (conjugated estrogens tablets, USP) family — $182 million, down 11%.
Data as of 12.31.19
About Premarin Horses
Premarin®, Prempro®, Premphase® and Duavee® are examples of the Premarin® family of drugs which are made with the the estrogen rich urine of pregnant mares.
In the ‘pregnant mare urine’ (PMU) industry, horses are repeatedly impregnated so their urine can be collected and made into hormone replacement products.
Some of the foals are rescued. Most, however, who can not be ‘repurposed’ in some way are sent to slaughter — seen as a byproduct of the industry much like male calves are in the dairy industry.
Alternatives to PMU Drugs
There are many alternatives to drugs made from the urine of pregnant mares.
Talk to your doctor. Visit your local pharmacy. There are prescription free over-the-counter treatments for hot flashes, vaginal dryness and other menopausal symptoms.
“I decided to speak out because I believe most women do not realize the hormone replacement therapy drug Premarin® actually stands for PREgnant MARe urINe, and that it is a billion dollar industry built on horse abuse and slaughter.”
~ Alexandra Gritta
Portland, OR (PRWEB) January 31, 2012
Alexandra Gritta, sixteen-year-old author and President of the Charity Book Series®, Inc., a 501(c)3 nonprofit corporation, announced today her charitable gift to Duchess Sanctuary in Oakland, Oregon. Gritta’s donation comes from the profit of her children’s book, “Mystery at Silver Key Stables,” and her own personal fund-raising efforts. Her charitable gift of $10,000 brought another $10,000 in matching funds from the Humane Society of the United States, for a total donation of $20,000 to the Duchess Sanctuary.
More than 180 rescued horses are allowed to roam free on the 1,120 acres of land at Duchess Sanctuary, a rural property outside of Roseburg, Oregon, run by the Fund for Animals in partnership with The Humane Society of the United States (HSUS). Jennifer Kunz, Duchess Sanctuary Ranch Manager, reports that among these are 100 mares and foals rescued from Canadian Pregnant Mare Urine (PMU) farms. After visiting the Duchess Sanctuary in July 2011, Gritta was inspired by the genuine love and concern that Jennifer Kunz has for the horses she has cared for since their rescue.
Celine Myers, founder of the Ark Watch Foundation, rescued the PMU mares that now call Duchess home. Myers reports that these mares were formerly used at Canadian PMU farms where their urine was collected and used by Wyeth Pharmaceuticals, a division of Pfizer, in the manufacture of hormone replacement therapy drugs, including Premarin®. A Duchess Sanctuary video clip released by the Humane Society of the United States (6/24/2011) depicts how PMU mares are kept in a constant state of pregnancy, forced to wear plastic urine collection devices, and tied up for six months of every pregnancy in stalls so small the mares cannot even turn around. After foaling, the mares are immediately impregnated again and the brutal cycle repeated.
Although horse rescue organizations try desperately to save as many PMU horses as possible, according to Vivian Grant Farrell, founder of the International Fund for Horses, “Live PMU foals, by-products of the endless horse pregnancies necessary to manufacture Premarin®, are typically sent to auction where they fall prey to slaughterhouse buyers. Sometimes the foals are shipped in live loads to foreign markets for slaughter. When the exhausted PMU mares finally wear out, they too often end up in the hands of slaughter buyers. Conservatively speaking, hundreds of thousands of PMU mares and foals have probably died in connection with the manufacture of the Premarin® family of drugs. Taking into consideration the quantity of pregnant mare urine required to make Premarin® and its high volume of sales, that number is quite possibly as high as a million, probably even higher. These numbers, of course, will continue to climb as long as women continue to choose to take drugs manufactured from pregnant mare urine.”
Alexandra Gritta: “I decided to speak out because I believe most women do not realize the hormone replacement therapy drug Premarin® actually stands for PREgnant MARe urINe, and that it is a billion dollar industry built on horse abuse and slaughter.”
A Stock Markets Review article, dated May 18, 2010, reports Pfizer/Wyeth now has another drug in the pipeline, awaiting FDA approval and intended to be marketed as a drug for both osteoporosis and post-menopausal symptoms. The new drug Aprela® is also manufactured from pregnant mare urine. This news bodes ill for horses, as the market for Aprela® has the potential to be even more lucrative for the pharmaceutical manufacturing industry than Premarin®, with Epsicom Business Intelligence forecasting future worldwide sales for osteoporosis drugs to be nearly US$14 billion by 2014.
Alexandra Gritta: “The amount of pregnant mare urine that will be required for Pfizer/Wyeth to continue to manufacture Premarin® plus its new drug Aprela®, if it is approved, is unimaginable. It is even harder to imagine the suffering and the slaughter of the horses that will be necessary to provide it.”
At the 2009 American Society of Clinical Oncology meeting in Orlando, researchers announced that women who take hormone therapy (HT) are 60 percent more likely to die from lung cancer if they develop it.
But Wyeth’s Joseph Camardo, MD didn’t let the report curb his enthusiasm for the Prempro franchise. Or the report at a medical conference the previous year that HT doubles risk for breast cancer in five years and increases it in two.
Younger women between aged 51 to 54 are starting to use HT he told reporters and “the same risks may not apply with the new patterns of use!”
For over eight years, hormone makers have tried to revive HT sales which sank in 2002 with a “timing theory.” Women shouldn’t take less hormones says pharma, they should take more and they should start taking them earlier, goes the theory.
(In Chicago, the timing theory is called voting early and often.)
The women in the Women’s Health Initiative who got 29 percent more breast cancer, 26 percent more heart disease, 41 percent more stroke and double the amount of blood clots on Prempro wouldn’t have gotten the lethal quartet if they weren’t so old, went the theory. Their average age was 63! If women start HT around 50, it well might well prevent heart disease and cognitive decline says the timing theory.
Of course you have to admire pharma’s audacity. Despite the HT-caused endometrial cancer epidemic in the 1970s which fell when women quit Premarin, despite the HT-caused breast cancer epidemic which fell when women quit Prempro in 2002, they’re sticking to their story gosh darnit. READ FULL REPORT >>