Premarin, doctors and conjugated equine estrogens

March for Premarin Horses featured image.
The Premarin family of HRT drugs is made from the urine of pregnant mares.

Updated: 1:50 pm

MORE and more doctors who prescribe Premarin® are arguing with us that the menopausal drug no longer contains conjugated equine estrogens derived from pregnant mare’s urine. Huh?

The idea doctors most often cite in support of this belief is what it says on the drugs’ packaging, that Premarin® is made from “conjugated estrogens” where it used to say “conjugated equine estrogens”. Removing the word equine is something Pfizer pressed the FDA to do shortly we believe after they merged with or acquired Wyeth pharamaceuticals, adding these drugs to their portfolio. The removal of the word equine is obviously having its desired effect.

Premarin sample package with words "conjugated estrogens". Google search result. Unattributed image.
Premarin sample package with words “conjugated estrogens”. Google search result. Unattributed image.

Well dear doctors. A quick check on the internet should assure you that the Premarin® family of drugs including Duavee (originally called Aprela) which we don’t hear much of, has and assuredly always will be made with CEE’s — conjugated equine estrogens.

Wikipedia

Conjugated estrogens (CEs), or conjugated equine estrogens (CEEs), sold under the brand name Premarin (a contraction of “pregnant mares’ urine”) among others, is an estrogen medication which is used in menopausal hormone therapy and for various other indications. Read more »

RxList

PREMARIN® (conjugated estrogens tablets, USP) for oral administration contains a mixture of conjugated estrogens purified from pregnant mares’ urine and consists of the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. Be sure to check out the side effects. They include endometrial cancer, cardiovascular disorders, breast cancer and probably dementia. Read more »

DrugBank

Conjugated Equine Estrogens (CEEs) are derived from the urine of pregnant mares and contain a blend of at least 10 estrogen derivatives. Marketed under the brand name Premarin, CEEs are the most frequently used form of conjugated estrogens.

All estrogen products mimic the effects of endogenous estrogens in the body which are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics.

Conjugated estrogens, or Conjugated Equine Estrogens (CEEs) are composed of a mixture of the water-soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids that are purified from pregnant horse urine. Available as the product Premarin (FDA), this combination of equine-derived estrogenic compounds is indicated for the following conditions: treatment of moderate to severe vasomotor symptoms and vulvovaginal atrophy associated with menopause; hypoestrogenism due to hypogonadism, castration or primary ovarian failure; palliation of metastatic breast cancer; palliation of advanced androgen-dependent carcinoma of the prostate; and for prevention of postmenopausal osteoporosis. Read more »

PubChem

Premarin is a pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate. Read more »

See also NCBI » See also MedScape for Black Box Warnings such as increased risk of invasive breast cancer »

We get the picture. Surely doctors will now too.

Take Action

Dear Doctor Letter

Print and mail this letter to your doctor.

• PREMARIN_Dear_Doctor_Letter_UPDATED_October_2018_WORD (pdf, 4 pp)

Send this letter whether you are male or female. Doctors are known to use Premarin® intervenously to prevent bleeding during surgery.  So you may be treated with Premarin® without even knowing it or giving your permission. More to come on that so stay tuned here.

In the meantime, share far and wide. Save the horses!

China

The biggest challenge outside of the US is educating the Chinese who produce more pregnant mare’s urine and prescribe it more than anyone else in the world according to a recent source in China. And the Chinese love horse meat. So the two — Premarin® and horse slaughter — continues to go hand in hand.

Premarin tables. If you look closely you can see a legend in Chinese. Google image.
Premarin tables. If you look closely you can see a legend in Chinese. Google image.
Chinese version of Premarin cream.
Chinese version of Premarin cream.

In the meantime, doctors in the US are still prescribing and using the Premarin® family drugs at an alarming rate and seemingly unaware of the history and multiple dangers associated with this despicable drug.


Nothing has been, or ever will be, appealing or beneficial about the PMU industry and the Premarin family of drugs; they are clearly harbingers of death from both sides of the equation”.
– JANE ALLIN


Related Reading

•  Update! Alternatives to drugs made with pregnant mare’s urine by Jane Allin »

A look at a PMU farm in China and its not all about Pfizer »

Premstoppers

Premstoppers  is a Horse Fund campaign to eliminate drugs made with pregnant mare’s urine and their decades old legacy of cruelty and death.

Learn more at the Horse Fund website »

Donate

Donate to Premstoppers »

Thank you!

Unsanctioned horse racing flourishing in rural Colorado

DENVER, Colorado. KDVR FOX31. Chris Halsne and Chris Koeberl reporting. (May 18, 2017)  — Hidden cameras capture doping, gambling and abuse of horses as regulators, politicians, and law enforcement turn a blind eye. Go to full investigative report »

It’s Easter Sunday outside the Deer Trail Rodeo grounds.

Armed teams of private security in flak jackets set up a road block searching passengers and vehicles. What they are looking for is unclear, but alcohol and beer are allowed to pass. An Arapahoe Sheriff’s deputy drove by slowly on the street outside the stadium, but did not stop.

By early afternoon, approximately 500 spectators are lined up along metal railings near a long, manicured dirt track.

They were drawn here by an online advertising push from a company calling itself Parejeras Racing USA.

A Spanish language flyer promised 10 “match-races,” with prize money in the thousands of dollars.

At first glance, the horse races looked much like the legal, sanctioned ones held at Colorado’s only licensed horse race facility, Arapahoe Park in Aurora.

Jockeys, in colorful silk, mounted muscular Quarter horses draped with matching blankets embossed with large numbers. Handlers helped guide the horses and riders to a metal starting gate.

As the horses charged down the straight-away, it became apparent, there were few rules.

Whipping of the animals was harsh and nearly nonstop.

In one race, a jockey veered his horse into another competitor. The high-speed ramming pushed the thundering beasts toward spectators standing within inches of the track, including children.

In two other races, jockeys lost their balance and went tumbling among the hoofs of other race horses.

Problem Solvers, working with knowledgeable insiders, acquired hidden camera footage of not only the races, but all the activities happening just off the track.

Audio and video recordings show plenty of cash being wagered on horses. Continue reading at source »


 Drugging

Image source: KDVR.
Image source: KDVR FOX31.

The drugging of the horses is rampant and potentially lethal.

Hidden camera footage revealed a brown liquid being injected into a racehorse’s neck who moments later was entered into the starting gates and raced.

The liquid in the syringe was described as “ ‘typically a cocktail of stimulants’ to ramp up the horse’s heart – to get it to run faster”.

Equine veterinarian Bruce Connelly stated, “I’ve seen match-race horses run blind. Break themselves up because of stuff that was put in ‘em that shouldn’t have been.”

Local Law Enforcement

The problem is, the report points out, is that law enforcement and the Colorado Department of Revenue, which oversees some 1,400 pages of racing regulations, can take action only in sanctioned horse races. Adding “it seemed impossible to FOX31 that such a large event, widely advertised and attended by so many people could go unnoticed by local politicians.”

Oh, it hasn’t gone unnoticed by local politicians or law enforcement. They have either turned a blind eye to it like that Arapahoe Sheriff’s deputy who drove slowly by and didn’t stop, or profited by it, or both.

What about the Mayor?

According to state records, Deer Trail mayor, Kent Vashus is the “registered agent” of the Deer Trail Jockey Club. The Jockey Club is one of the oldest non-profits in Colorado and owner of the Rodeo grounds where the unsanctioned Easter races were held.

Vashus admitted to the FOX31 Problem Solvers he had allowed Parejares Racing USA to use the Rodeo grounds for races in the past. Records show he approved at least fourteen “Mexican Horse Races” in Deer Trail since 2015.

There is much, much more including video reports. This is an in-depth undercover report and one of the best we have seen in a very, very long time.

Take Action Colorado Residents

The Governor

Contact the Governor and register your concern using his online form.  Ask him to take immediate action against unsanctioned horse racing and the horrific abuses of the horses used for it.  Notwithstanding the horses, onlookers including children are put at risk of injury and even death. Share this shortened link to the full KDVR investigative report with him — https://goo.gl/ajkEFl.

Colorado General Assembly

The Colorado General Assembly adjourned May 10, 2017 and reconvenes January 10, 2018.

(1) Contact your individual legislator stating this is an important issue to you and you wish to see it on the next Session’s agenda. Share this shortened link to the full KDVR investigative report —  https://goo.gl/ajkEFl.

(2) Contact the following Colorado lawmakers urging them to place this issue on the next Session’s agenda and enact all laws necessary to make these unauthorized races illegal. Be sure to share the link to the full KDVR investigative report —  https://goo.gl/ajkEFl.

• Speaker of the House, Cristanta Duran (crisanta.duran.house@state.co.us)
• House Majority Leader, K.C. Becker (kcbecker.house@state.co.us)
• House Minority Leader, Patrick Neville (tim.neville.senate@state.co.us)

• President of the Senate, Kevin Grantham (kevin.grantham.senate@state.co.us)
• Senate Majority Leader, Chris Holbert (chris.holbert.senate@state.co.us)
• Senate Minority Leader, Lucia Garcia  (leroy.garcia.senate@state.co.us)

Oh, and throw that unscrupulous Mayor of yours Kent Vashus out on his ear next election Deer Trail residents.


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The image of the horse looking out from under the stands was taken at the Deer Trail Rodeo Grounds and is used here for illustrative purposes only. The image was not filed with the source report.

Horse protection advocates meet with Congressman Wednesday on soring rule

Stacked shoes of a sored Tennessee Walking Horse. HSUS image.

WASHINGDON, DC (Mar. 26, 2017) — Early on Sunday evening, Clant Seay, founder of Citizens Campaign Against Big Lick Animal Cruelty (CCABLAC), released a short video in which he affirmed an event scheduled for Wednesday in Washington, DC and an appearance with a congressman.

The group had previously scheduled the presentation of its petition containing 100,000 signatures to the White House and a subsequent press conference at the National Press Club on Wednesday, March 29.

Standing at the location of Donald Trump’s inauguration, Seay said that in addition to presenting the petition and holding the presser, the group will be meeting with Rep. Ted Yoho of Florida’s third congressional district, who is a large-animal veterinarian and former businessman.

The group will speak in the Edward R. Murrow Room at the National Press Club at 1:00 p.m. on Wednesday.  The address is 529 14th St. NW, Washington, D.C. 20045.

The change.org petition, posted several months ago, is showing 99,744 signatures as of press time and asks OMB Director Mick Mulvaney, as-yet-unconfirmed USDA Secretary Sonny Purdue, President Donald Trump and daughter Ivanka Trump to publish a federal rule supportive of the Horse Protection Act of 1970 which would ban “pads and chains” used on Tennessee Walking Horses during horse shows.

In his announcement on Sunday, Seay said that Yoho plans to “reintroduce the PAST Act,” a proposal first raised in 2013 with bipartisan support which encountered a number of obstacles and did not become law.  “PAST” stands for “Prevent All Soring Tactics” and is intended to eliminate soring by assigning inspections only to those without a conflict of interest.  Continue reading »

SOURCE
The Post and Mail »

SIGN PETITION
Change.org »

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Stacked shoes of a sored Tennessee Walking Horse. HSUS image.

Entrepreneurial lessons to be learned from thinking like a horse

MARCH AGAINST HORSE SLAUGHTER — We share a quick story before we resume our work here for March Against Horse Slaughter. We have a lot coming up, so stay tuned. Be ready to take part.

In the meantime check this out. The story, “3 Entrepreneurial Lessons I Learned from Raising Horses” caught our attention. And kept it.

Here’s a quick sketch of what these three lessons are. Go here to read the full story »

1. Pedigree doesn’t determine success. That’s self-explanatory.

2. Don’t Be a Reactionary: “. . . horses have two sides of their brain, a thinking side and a reactionary side, and the key is getting the horse to use the thinking side. . . Nine times out of 10, the thinking response is better”.

3. It’s never too late. The example they give is a lady who dreamed her whole life of learning to ride a horse. “She didn’t stop dreaming, though, and at the age of 67, she started riding.”

Sound Advice for the Entrepreneur and Advocate

Isn’t all of the above good, sound, workable advice concerning what we do as horse advocates?

How often does it look like it is a thankless, endless task to end the myriad abuses inflicted on horses like horse slaughter? That we can only dream about getting rid of it?

The definition of an entrepreneur is a person who organizes and manages any enterprise usually with considerable initiative and risk.

Everything is possible. It’s a question of risk, initiative, hard work and sticking with it — that’s the entrepreneurial spirit!

And like the lady who began riding horses at the age of 67, it is never too late to start.

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Bureau of Land Management