In our mission to help horses and foals used and cast off by the pregnant mare’s urine industry that make drugs like Premarin cream and tablets, we urge women to shun them and the cruelty that goes with them, and find an alternative to ease menopausal symptoms.
AMAG Pharmaceuticals has big ambitions for its women’s health business, so it’s snapped up the rights to a new med, Intrarosa, to beef up that portfolio.
The company plans to tout Intrarosa’s safety profile to set it apart from established estrogen-based treatments such as Pfizer’s Premarin cream and Estring vaginal ring. The AMAG drug, which contains the hormone precursor prasterone, has a “similar efficacy profile,” CMO Julie Krop said this week. “[F]rom an efficacy standpoint, I don’t see that there is particularly differentiating advantage,” Krop said. “It’s really on the safety side”.
The company clearly sees big potential for Intrarosa. AMAG will pay Endoceutics $50 million up front, plus 600,000 shares of newly issued common stock, which closed Tuesday at $22.65. Follow-up sales milestones add up to $45 million if Intrarosa surpasses $300 million in sales over time.
AMAG says it’s adding those 150 reps to its current team of 100, who now focus on its preterm labor drug Makena and cord blood registry (CBR). For now, the new salespeople will exclusively handle Intrarosa, a non-estrogen treatment for vaginal pain during intercourse, which often affects post-menopausal women”.
Unlike conventional pharmacological estrogen-containing medications, Intrarosa does not carry a boxed safety warning in its label.
Intrarosa enters an existing billion dollar-plus market for intravaginal prescription therapies that treat VVA symptoms. There are an estimated 64 million post-menopausal women in the U.S., and as many as 32 million women suffer from VVA symptoms.
VVA, or vulvar and vaginal atrophy, causes pain during intercourse (dyspareunia), a common symptom of menopause”.
Jane Allin, horse advocate and expert on drugs made with pregnant mare’s urine such as Premarin® cream which is also prescribed for dyspareunia, states:
“This drug is a steroid — prasterone — of which estrogen is a metabolite so carries with it the same risks as other estrogen substitutes for Premarin® (i.e. the use of exogenous estrogen is contraindicated in women with a known or suspected history of breast cancer).
“So basically it’s just another form of estrogen that isn’t derived from horse pee. Safer but still has risks associated with estrogen.
“It would be nice if the pharmaceutical companies could come up with something that isn’t a steroid/estrogen. But that’s all they seem to know — and because it’s easy”.
Is this good news for the mares and foals used and cast off by the Premarin® industry?
“Intrarosa may cut into Pfizer’s Premarin® vaginal cream profits some but I doubt it will ever be enough that Pfizer would discontinue its sale”, states Vivian Farrell of The Horse Fund, “which is the only way the success of this new drug could help the horses used by the Premarin® industry in N. America.
“The popularity of Intrarosa may spare a few mares and foals along the way but it doesn’t appear it will spare women from the potential risk of breast cancer”.
Premarin horses (or PMU horses) are the mares and foals cruelly exploited to produce the Premarin® family of drugs made for the relief of menopausal symptoms in women.
The key component of these drugs comes from the estrogen rich urine collected from pregnant mares on what are commonly called “pee lines” in the industry.
PMU horses are purpose bred to produce Premarin® type drugs.
The resulting foals become unwanted byproducts and typically sold off at auction where they are in danger of being bought by “meat men” working on behalf of slaughterhouses. Some of these foals are shipped live to Japan to feed the highly popular sushi market.
Mares who can no longer become pregnant are also routinely cast off by the industry and exposed to the risk of slaughter.
In 2016 Horse Fund advocates and followers of Tuesday’s Horse took more action and viewed and shared more articles and information on the Premarin® Horses issue than any other horse cruelty issue.
You alerted us whenever you saw ads for Premarin® tablets or cream on television, in magazines and on YouTube. We contacted the advertisers and these ads were removed or not renewed, rarely appearing again. If they did resurface, you were on it and so were we.
The scientific term for the estrogen rich component contained in pregnant mare’s urine is conjugated equine estrogens (CEE’s).
With your help we were able to send out more than 33,000 Dear Doctor letters in 2016 warning physicians about the presence of CEE’s in the Premarin® family of drugs.
A bone of contention between us and certain doctors arose over labeling.
Notably, some years ago the word equine was removed from Premarin® packaging stating the drugs were made with conjugated estrogens.
This was done in spite of the fact that the World Health Organization declared that conjugated equine estrogens are known carcinogens — in other words they have cancer causing properties. In our opinion the US Food and Drug Administration (FDA) in this regard are operating in a dangerous and immoral manner by allowing the mislabeling of Premarin® in this way.
Conjugated estrogens can also be derived from plants. The ingredient necessary to make Premarin® must be gotten from equines.
Yet there were doctors who continued to argue the point and said they had no problem prescribing Premarin®. They even went so far as to defend the labeling stating that the FDA would not be so reckless with people’s lives.
However, it is crystal clear.
The key ingredient in the making of Premarin® type drugs is derived from pregnant mare’s urine.
We are pressing hard for the FDA to enforce correct labeling and will continue to do so. However in the current political climate it is likely to be tougher than ever.
By the way the Premarin® family of drugs includes Duavee® (originally named Aprela in all by the final stage of the FDA’s approval process) is an almost identical drug also made by Pfizer. But for reasons unknown they have marketed it very little in the US or abroad.
The largest market for Premarin® type drugs is in China where they are producing what appears to be a copycat drug.
The Xinjiang Xinzi Biopharmaceutical Limited Liability Company reportedly uses the urine of pregnant mares as the source to successfully develop estrogen drugs, claiming they are one of two companies in the world doing this, the other being Wyeth and bought out by Pfizer.
Did Pfizer sell or make some sort of deal with the Chinese for the formula? Or did they have to considering the status of the drug’s patent?
Here is what it looks like inside one of the Chinese labs.
Here is what Chinese packaging looks like for the Premarin® like cream.
The numbers are very scary. The number of women reaching the menopausal stage in China is many millions more than any other place in the world.
It is up to us to warn them about the cancer causing properties connected to Premarin® type drugs. It is the only way we can help these horses.
That is our mission for 2017.
Menopause is not a disease. Menopausal symptoms — although they can be most unpleasant and in some instances seem debilitating — are not life threatening and can be successfully treated.
No human or animal needs to be exposed to suffering or death in order to be provided with relief from menopausal symptoms. There are alternatives.
Here’s another terrific recipe. I just got through tasting it down at my neighbor’s. She has become our test kitchen but is moving back to Atlanta and going to culinary school to become a Vegan Chef. We are so excited for her but we are going to miss her so.
5 cups rhubarb, chopped into 1″ pieces
2 lemons, juiced
5 tablespoons honey (sub agave for true vegan)
3/4 cup almond flour
3/4 cup pecans
3/4 cup dates
1/2 teaspoon sea salt
3 cups cashews, soaked overnight
1/4- 1/2 cup lemon juice (start with 1/4 add more to taste)
1/4 cup maple syrup
1/2 cup coconut oil
1/4 teaspoon sea salt
Coconut Milk Whipped Cream
1 can full fat coconut milk, refrigerated for 24 hours
1-2 tablespoons maple syrup, to taste
“The rhubarb’s slender red and green stalks contain a singular set of nutrients that make it a healthy vegetable.
“In fact, we owe a debt of gratitude to ancient Chinese folk medicine for the background work on rhubarb cures and remedies that today’s scientist have substantiated and expanded on:
• fiber for ease in digestion
• vitamin K for healthy bone growth and neuron function in the brain
• natural antioxidation from vitamins C and A
• anti-infection properties
• healthy skin, mucous membranes and vision
• potential cancer protection
Other vitamins, minerals, and phytonutrients in rhubarb, including outstanding amounts of calcium, offer essential support and optimal health benefits throughout the body.” See source.
Jane Allin just taught us that rhubarb can also ward off the symptoms of menopause.
Wouldn’t it be nature’s great joke on Pfizer if simply adding rhubarb to our diets made its carcinogenic drugs derived from animal waste (i.e. Premarin = pregnant mare’s urine) obsolete.