Report Premarin® ads on behalf of women and horses

Trio of Rescued Premarin Foals. Photo: Vivian Grant Farrell

PREMSTOPPERS — Premarin® is made from the estrogen rich urine of pregnant mares. The World Health Organization listed the conjugated equine estrogens (CEE) made from pregnant mare’s urine as a known carcinogen.

Numerous class action lawsuits filed by women over the years in the U.S. and Canada point to the cancer causing properties of CEE drugs. There are many examples of these types of lawsuits. Here is one.

In an article entitled, “Cancer linked to menopause drug in new report“, it states “In 2014, Pfizer, which in 2009 acquired Wyeth, has paid $1.7 billion to settle nearly all of the 10,000 hormone replacement therapy claims against the drug manufacturer. Pfizer said it makes no admission of liability in the American settlements”.

In the meantime, the USDA allowed Pfizer at some point during all of this to package their line of CEE drugs such as Premarin® with the wording “conjugated estrogens” in place of “conjugated equine estrogens”.

Premarin® sample package with words
Premarin® sample package with words “conjugated estrogens”. From

Unbelievably this labeling fools even some doctors who are either in denial or merely pretending to be for the perks they receive for prescribing it.

Putting a stop to Premarin® ads is one way we can act on behalf of women and horses.

The Ads — Premarin® Cream

Most of the ads you currently see are for Premarin® Cream.

Premarin Cream® ads appear most often in magazines like Oprah, Good Housekeeping and Ladies Home Journal. We have contacted Oprah magazine many times and the ad disappears only to reappear. Oprah supposedly has and loves horses and is dedicated to women’s issues. So Oprah’s advertising of Premarin® does not add up, does it?

Premarin® Cream ads also appear on television and on YouTube as you will see below. You will also see them  in those quick advertising spots before the YouTube video you selected begins.

Take a look at this. There are more reasons not to take it, than to take it. Published on YouTube by David O’Neill.

LouisePatti commented on this video, “My dearest, most beautiful cousin, Debi, who was less than a year younger than I was died of cancer from taking some prescription hormonal cream. The last time I saw her she told me what had caused the cancer. I had just been prescribed this a few days earlier. She looked young and healthy the last time I saw her, but 2 months later, she had passed away. She might have saved my life, and God willing, she will help many others.”

The abuse and death of horses does not come into it of course. And yes, there are alternatives to Premarin®.

Take Action

It’s simple. Be our eyes and ears. When you see an ad for any Premarin® type product let us know using this special Contact Form and we will take it from there. You may want to take a quick look at it so you can see the type of information we need.

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Featured Image

Trio of Premarin® foals rescued from Canada. Photo: Vivian Grant Farrell.

Last updated: 7:28 pm.

AMAG snaps up rights to new med Intrarosa to compete with Pfizer’s Premarin® vaginal cream

Tracy Staton reporting for writes as follows.

AMAG Pharmaceuticals Logo

Caslon Quote Left BlackAMAG Pharmaceuticals has big ambitions for its women’s health business, so it’s snapped up the rights to a new med, Intrarosa, to beef up that portfolio.

The company plans to tout Intrarosa’s safety profile to set it apart from established estrogen-based treatments such as Pfizer’s Premarin cream and Estring vaginal ring. The AMAG drug, which contains the hormone precursor prasterone, has a “similar efficacy profile,” CMO Julie Krop said this week. “[F]rom an efficacy standpoint, I don’t see that there is particularly differentiating advantage,” Krop said. “It’s really on the safety side”.

The company clearly sees big potential for Intrarosa. AMAG will pay Endoceutics $50 million up front, plus 600,000 shares of newly issued common stock, which closed Tuesday at $22.65. Follow-up sales milestones add up to $45 million if Intrarosa surpasses $300 million in sales over time.

AMAG says it’s adding those 150 reps to its current team of 100, who now focus on its preterm labor drug Makena and cord blood registry (CBR). For now, the new salespeople will exclusively handle Intrarosa, a non-estrogen treatment for vaginal pain during intercourse, which often affects post-menopausal women”.

"Premarin Vaginal Cream could result in more comfortable sex, uterine cancer, heart disease, heart attacks, stroke, dementia, blood clots or breast cancer."
“Premarin Vaginal Cream could result in more comfortable sex, uterine cancer, heart disease, heart attacks, stroke, dementia, blood clots or breast cancer.” Click to be taken to source article.

NASDAQ, in its press release on the licensing and introduction of Intrarosa states:

Caslon Quote Left BlackUnlike conventional pharmacological estrogen-containing medications, Intrarosa does not carry a boxed safety warning in its label.

Intrarosa enters an existing billion dollar-plus market for intravaginal prescription therapies that treat VVA symptoms. There are an estimated 64 million post-menopausal women in the U.S., and as many as 32 million women suffer from VVA symptoms.

VVA, or vulvar and vaginal atrophy, causes pain during intercourse (dyspareunia), a common symptom of menopause”.

Jane Allin, horse advocate and expert on drugs made with pregnant mare’s urine such as Premarin® cream which is also prescribed for dyspareunia, states:

“This drug is a steroid — prasterone — of which estrogen is a metabolite so carries with it the same risks as other estrogen substitutes for Premarin® (i.e. the use of exogenous estrogen is contraindicated in women with a known or suspected history of breast cancer).

“So basically it’s just another form of estrogen that isn’t derived from horse pee. Safer but still has risks associated with estrogen.

“It would be nice if the pharmaceutical companies could come up with something that isn’t a steroid/estrogen. But that’s all they seem to know — and because it’s easy”.

Is this good news for the mares and foals used and cast off by the Premarin® industry?

“Intrarosa may cut into Pfizer’s Premarin® vaginal cream profits some but I doubt it will ever be enough that Pfizer would discontinue its sale”, states Vivian Farrell of The Horse Fund, “which is the only way the success of this new drug could help the horses used by the Premarin® industry in N. America.

“The popularity of Intrarosa may spare a few mares and foals along the way but it doesn’t appear it will spare women from the potential risk of breast cancer”.

“Where the largest threat to horses used and cast off by the PMU drug industry in terms of numbers is of course China where the copycat Premarin® cream they are manufacturing themselves is being marketed to untold millions of women”.

Packaging for Premarin like vaginal cream in China.
Packaging for Premarin like vaginal cream in China.


• “AMAG to hire 150 new sales reps to tout newly licensed women’s health med Intrarosa”, by Tracy Staton,, Feb 15, 2017.

• “FDA approves Intrarosa for postmenopausal women experiencing pain during sex”, FDA News Release, Nov 17, 2016. Prasterone page. Intrarosa label (pdf, 1p).


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People’s Pharmacy: Dr’s troubling advice and Premarin Cream

Say No to Premarin (tablets and cream), Duavee and Duavive. They are made with urine of pregnant mares, the byproduct foals cast off, slaughtered.
Say No to Premarin (tablets and cream), Duavee and Duavive. They are made with urine of pregnant mares, the byproduct foals cast off, slaughtered.

Before I show you what I found in a People’s Pharmacy article, I must ask: Aren’t there plenty of lubricants that women of any age can use? Does a woman of a certain age really need something that a younger woman doesn’t? Premarin Cream to our way of thinking is extremely dangerous business — and not just to the horses — and unnecessary.

Found on

Q. I was diagnosed with uterine and ovarian cancer last year. After a complete hysterectomy and months of chemo, I talked to my GYN/oncologist about vaginal dryness.

He prescribed Premarin cream. He said it’s very low-dose estrogen and not absorbed into the bloodstream, unlike estrogen pills that are not advised for someone like me who has had a hormonal cancer. He told me that the risk of developing breast cancer from this cream is incredibly small. He’s the head of the department and a GYN/oncologist for more than 25 years, so he should know.

A. The makers of Premarin Vaginal Cream specifically warn that it should not be used if you have had breast or uterine cancer, a stroke or heart attack, blood clots or liver problems. During a current TV commercial for Premarin Vaginal Cream, the voice-over says, “Estrogens may increase your chances of getting cancer of the uterus, strokes, blood clots or dementia.” This suggests that estrogen is absorbed from the vagina.

You will find other ideas about easing vaginal dryness in our Guide to Menopause. Anyone who would like a copy, please send $3 in check or money order with a long (No. 10), stamped (70 cents), self-addressed envelope to: Graedons’ People’s Pharmacy, No. W-50, P.O. Box 52027, Durham, NC 27717-2027. It also can be downloaded for $2 from our website:


Why do we care so much about Premarin Cream on a horse protection blog. Because this evil mess is made with animal waste, namely Pregnant Mare’s Urine.

You can see where the names Premarin comes from. But Pfizer who are responsible for this drug have more bad news for women and horses with their latest additions to the Premarin family of drugs — Duavee (in the U.S.) and Duavive (in Europe).

For women taking “horse pee” drugs, beware ladies. Beware.

Please ladies, don't take horse pee drugs. Say NO to Premarin, Duavee and Duavive!
Please ladies, don’t take horse pee drugs. Say NO to Premarin, Duavee and Duavive!


• See Premstoppers >>

We love the article (see below). It will help women wondering about menopausal symptoms and their sex lives. Strictly about women; doesn’t even mention the horse abuse from the making of these drugs.

• See “Premarin Vaginal Cream could result in more comfortable sex, uterine cancer, heart disease, heart attacks, stroke, dementia, blood clots or breast cancer”; Natural Menopause Now;

Pushing Premarin: Big Pharma, Big Bucks — Part 2


Safety: Big Pharma, Bad Medicine

Premarin foals in feedlot.
Premarin foals in feedlot.

Despite Pfizer’s aggressive marketing strategies, the sad fact is that these drugs derived from horse urine are the same drugs they always were – the drugs that took the lives of thousands of unsuspecting women and continue to exploit and abuse the PMU mares and their foals.

They have the same risks they have always had and the package warnings list even more risks than before as a result of Wyeth’s past indiscretions and failure to sufficiently warn the public of the dangers. Yet they’re deemed safer because of this very reason – make the consumer aware, we aren’t hiding anything – honest.

And, while it’s true that the “recommended” prescribed dosages may be lower along with guidelines that advise reducing the length of time a woman remains on HRT, in effect nothing has changed – they are still recognized as carcinogens by the WHO and other regulatory bodies.

    In women, a recent study has evaluated the potential of HRT to induce DNA damage in peripheral blood leukocytes of postmenopausal women using the comet assay (Ozcagli et al. 2005). Significant increases in DNA damage were observed among women receiving 0.625 mg/day conjugated equine estrogens or conjugated equine estrogens plus medroxyprogesterone acetate as compared to the control group that had never received HRT. Finally, the excessive production of ROS in breast cancer tissue has been linked to metastasis of tumors in women with breast cancer (Malins et al. 1996; Malins et al. 2006; Karihtala and Soini 2007; Benz and Yau 2008). These and other data provide a mechanism of estrogen-linked tumor initiation/promotion by redox cycling of estrogen metabolites generating ROS, which damage DNA.” [1]

ROS stands for “Reactive Oxygen Species”. Various carcinogens, such as CEEs, may partly exert the effect of oxygen derived species (e.g. superoxide radical) by generating reactive oxygen species (ROS) during their metabolism. Oxidative damage to cellular DNA can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis.

Science says 0.625 mg/day can induce DNA damage and cancer. Today Premarin tablets are still available in dosages of 0.3 mm, 0.45 mg, 0.625 mg, 0.9 mg and 1.25 mg. And physicians continue to prescribe various doses depending on the severity and nature of menopausal symptoms. By comparison Premarin cream contains 0.625 mg per dosage and Duavee 0.45 mg together with 20 mg of bazedoxifene, a drug yet to be approved on its own by the FDA. Is a dosage of 0.45 mg really safer than 0.625 mg? And what about Premarin cream at the same 0.625 mg level?

And let’s not forget about the innocent bystanders, not just the vulnerable women who opt to take these drugs for relief of menopausal symptoms, either of their own volition or on the advice of their doctors.

What many may not be aware of is that creams, lotions and other topical skin products can be absorbed through the skin and into the systemic circulation resulting in unexpected complications.

Since the release of the damaging WHI results demonstrating the risks involved with the Premarin family of drugs, the use of topical hormones such as Premarin cream have escalated. When HRT drugs are applied topically rather than taken orally they avoid the “first-pass” effect through the liver which is generally considered a “safer” route.

    The advantage of this route of administration is that oestrogen is delivered directly to oestrogen-depleted tissues with similar efficacy to oral oestrogen, with the hope of avoiding significant systemic absorption and consequent side-effects. Given some concerns surrounding the safety of systemic HRT, particularly on breast tissue and the coagulation cascade, topical HRT offers a more targeted approach.” [2]

At the same time there are limited studies on the effects of topical estrogens and, in practice, systemic absorption is lower but not negligible and increases with increased doses of estrogen. [3]

And it isn’t simply the women who use Premarin vaginal cream who are at risk – their partners are also exposed to the estrogens in this topical HRT during intercourse which can pose harmful and unwelcome side effects.

According to the North American Menopause Society, vaginal creams such as Premarin should not be used right before sex because the partner may absorb the estrogen hormone through his skin (Journal of Reproductive Medicine, Jan. 2008).

Over time estrogen could have a feminizing effect on a man. [4]

    A few months back I received an email from a reader whose husband was inexplicably gaining weight and growing breasts. She ordered a blood spot hormone test for him, and his results showed low testosterone and high estradiol (estrogen), which certainly explained his symptoms. After a bit of digging, we figured out that she was using a vaginal estradiol cream within a few hours of when she and her husband had intercourse. In fact, she considered it a vaginal lubricant. I suggested she switch to a low dose estrogen patch, and recently heard from her that within a matter of weeks her husband had started losing the weight, and after a couple of months his breasts were back to normal and by the way, so was his sex drive.” [5]

Another word of caution for any and all estrogen-containing topical products.

    Transferring estrogen to children can have serious consequences. For boys, who again are already over-exposed to estrogenic chemicals in the environment, even small amounts of estrogen can block normal development of male characteristics and stimulate weight gain and breast growth. For girls, exposure to excess estrogen can cause early puberty and menstruation, a known risk factor for breast and ovarian cancer later in life.” [6]

And if that’s not enough, even your canine and/or feline family is affected by topical estrogens. An article in the New York Times reports the following:

    Veterinarians around the country are reporting a strange phenomenon: spayed dogs and cats, even some puppies and kittens, are suddenly becoming hormonal.

    In female pets, the symptoms resemble heat: swollen genitals, bloody discharge and behavioral problems. Male animals are showing up with swollen breast tissue and hair loss. Standard treatments and even repeated operations have had no effect.

    Now vets have identified the culprit. The pets were all owned by women who used hormone creams on their hands, arms and legs to counter symptoms of menopause. Animals who licked or cuddled their owners, or rubbed up against their legs, were being inadvertently exposed to doses of hormone drugs.” [7]

Is it really worth it to take any form of estrogen for the relief of menopausal symptoms – Premarin or others?

Other synthetics carry with them the same or similar warnings associated with their use although it has been repeatedly cited in scientific literature that estrogens derived from pregnant mares urine pose a significantly greater risk due to the conspicuous fact that equine estrogens are foreign to humans but, wait for this . . . not horses. What a concept.

First note the disparities between the concentrations of estrone and estradiol and of course the presence of the equine estrogens found exclusively in horses – clearly problematic in relation to the safety profile of these drugs.

And a closer look renders CEE-derived HRT products even more sinister:

    Premarin contains at least 10 estrogens that are the sulfate esters of the ring B saturated estrogens: estrone, 17beta-estradiol, 17alpha-estradiol, and the ring B unsaturated estrogens: equilin, 17beta-dihydroequilin, 17alpha-dihydroequilin, equilenin, 17beta-dihydroequilenin, 17alpha-dihydroequilenin, and delta-8-estrone. Bioassays and estrogen receptor binding studies indicate that all 10 estrogens are biologically active. Moreover, individual components, such as equilin sulfate, delta-8-estrone sulfate, 17beta-dihydroequilin sulfate and estrone sulfate, have potent estrogenic effects. Since all of the estrogens present in Premarin have estrogenic activity, the pharmacological effects of Premarin are a result of the sum of these individual activities.” [8]

The extract of pregnant mare’s urine is nothing less than a dangerous cocktail of alien hormones with demonstrated and lethal side-effects.
The upshot is that, unlike the horse, the female human body does not have the necessary enzymes and co-factors required to metabolize equine estrogens nor does it have the ability to deal with the significantly higher concentrations of Estrone and Estradiol contained in any of the Premarin drugs. Certainly these disproportionate and foreign hormones must create a hormonal imbalance that can have serious antagonistic consequences.

    As two leading reproductive physiologists point out, when women take Premarin, ‘Levels [of equilin] can remain elevated for 13 weeks or more post-treatment due to storage and sloe release from adipose [fat] tissue. In addition, metabolism of equilin to equilenin and 17-hydroxyequilenin may contribute to the estrogen stimulatory effect of [conjugated estrogen] therapy.’ Another metabolite of equilin, 17-dihydroequilin has been found to be eight times more potent than equilin for inducing endometrial growth, a possible precursor to cancer (3). As a result, Premarin produces “estrogenic effects” which are much more potent and longer lasting than those produced by natural human estrogens.” [9]

The bottom line – CEEs still cause cancer and a host of other illnesses. Why on earth are these archaic medications still on the market? Simply put, they shouldn’t be.

    Equilin metabolites appear to have stronger carcinogenic effects than comparable oestradiol metabolites. Oestradiol is now available in pure form, crystalline or as oestradiol valerate, and it seems more sensible to replace the oestradiol deficiency by giving the exact hormone rather than an extract of uncertain composition. Since CEE offers no advantage over physiological oestradiol, it is hard to understand why substitution with a pharmacologically poorly defined oestrogen mixture is still practised. From the point of view of clinical pharmacology, the use of an oestrogen extract should now be considered inappropriate.” [10]

Exactly, there is absolutely no longer any need for these risky equine estrogens.
[3] Same as 2.
[6] Same as 5.

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ATTENTION! If you see an ad for any Premarin product including Duavee, please contact us and tell us what network, the channel you saw it on, the city and what it was for. Thanks.