WRITTEN AND RESEARCHED BY JANE ALLIN
Part 1 — Introduction
A billion dollars – lots of zeros.
And keep in mind not just a billion dollars, but a billion dollars or more year after year – this has been the profit margin of the Premarin® family of drugs since Pfizer‘s $68 billion acquisition of rival drug maker Wyeth in October 2009.
This collection of contemptible drugs was equally rewarding to Wyeth, one of the very reasons Pfizer lobbied for the takeover despite speculation — a takeover that was to be the biggest merger since AT&T and Bell South combined in a $70 billion deal in March 2006. 
Such a merger typically stifles competition and in this case furthers the power over the FDA and similar regulatory bodies. It is no secret that when it comes to NDAs (new drug approvals) and continued support of questionable medications that the FDA is intimidated by Big Pharma and bows to its demands due to financial incentives -– one need only look at the new combination osteo-menopausal therapy DUAVEE®.
More on that later.
Appalling? Certainly, but this is Big Pharma clout which, by nature, instructs the actions of FDA management and their minions.
“FDA’s own scientists report pattern of intimidation, censorship and scientific fraud that undermines public safety.
In a truly astonishing survey just released by the Union of Concerned Scientists, the Food and Drug Administration’s own scientists describe the agency as an environment of intimidation, censorship and scientific fraud. A survey of 997 FDA scientists revealed that forty percent feared “retaliation” for voicing safety concerns over prescription drugs in public. Over one-third of the scientists didn’t even feel safe expressing safety concerns inside the agency, behind closed doors!
Intimidation and censorship have been well documented at the FDA, and this survey adds further weight to the evidence that the FDA has been utterly co-opted by the pharmaceutical industry and now serves Big Pharma’s commercial interests rather than anything resembling a commitment to honest science or public safety.” 
If this isn’t sobering enough think about the enormity of its effect on our day-to-day lives and the pill-pushing nation we live in.
Not only is it astounding that year after year Pfizer continues to successfully market and sell these HRT drugs despite their carcinogenic toxicity but even more so the fact that over 90% of the sales take place in the United States.
It is disheartening to think of how many women with access to proven evidence of the damage these drugs are capable of still buying into the propaganda doled out by their physician’s undying loyalty to Big Pharma.
Even more daunting is the realization that there exists an untapped market on the international level ready to be infiltrated by this drug Behemoth’s drive to peddle its deadly wares using deceitful marketing strategies and bribery.
And that untapped market is huge. According to a Bloomberg article “Drug Sales in Emerging Markets to Match US by 2016:
“China, India, Brazil, Russia are among 16 emerging markets that will make up almost one-third of global drug spending within four years, as newly wealthy people and nations spend more on health care, a report shows . . . .China is leading the growth in these markets.” 
No doubt this will have an impact on sales of the Premarin® family of drugs.
But I digress.
Getting back to the reason for this particular report, just how many mares are out there on the pee lines?
The gradual downsizing of the PMU ranches began shortly after the WHI results were released and now stand at approximately 22 farms after the shuttering of a farm in North Dakota in early 2012.
NAERIC (North American Equine Ranching Information Council), the non-profit association of equine ranchers engaged in horse production and management of pregnant mares here in North America claims there are approximately 2,000 broodmares involved in the equine ranching industry.  A far cry from 2002 and 2003 where there were as many as 300 PMU farms housing upwards of 50,000 or more mares churning out gallon upon gallon of estrogen-rich urine. 
While it is true that immediately following the release of the WHI study, citing the horrors associated with CEE-derived HRT, there was a precipitous drop in sales of Premarin® and Prempro®, much of that market was reclaimed in time via reduced dosage recommendations, aggressive marketing strategies, price increases and the wide availability of these drugs without prescriptions through Internet sales. This is clearly reflected in the continuing profits awarded Pfizer year after year.
Moreover it is common knowledge these days that there is a thriving PMU industry in China and possibly other foreign countries of the world.
This was revealed by The Horse Fund (working as the Int’l Fund for Horses) in March of 2012 wherein according to information procured from an inside source from a company manufacturing conjugated equine estrogens PMU farms had been in operation in Northern China for the last 8 years, now approximately 10 years.
The following May of 2012 a video entitled “Horse urine a profitable industry” aired on BONTVchina which made its way to North America late last year confirming their existence. 
While we are aware of the roughly 2,000 mares here in North America it would be interesting to have an indication of the total number of mares required to provide the amount of conjugated equine estrogens (CEEs) for the manufacture of this vile family of carcinogens.
There are several variables required to calculate this number:
- Concentration of CEEs in pregnant mares urine
- Change in concentration of CEEs over the collection period
- Average daily urine output
- Profits made per annum from the Premarin family of drugs
- Average cost of a dose of CEEs
- Average dose of CEEs in the HRT products
There is little transparency in the pharmaceutical industry and facts are hard to come by. Accordingly this assessment was a labor of desire in pursuit of answers which are not forthcoming from the PMU or pharmaceutical industry. Answers which are tenuous and may never be confirmed or denied given the tenacity of Big Pharma and its deceptive character.
Of the list of required information perhaps the most difficult to locate was the concentration of CEEs in pregnant mare’s urine. As much as the Internet provides a wealth of data on many subjects there was little in the way of isolating these concentrations in easy to interpret format. In many cases, specifically those from non-scientific articles and websites, the numbers were ridiculously impractical. Therefore why not go to the source?
Attempts at gleaning any information from Pfizer failed miserably – they were simply not going to divulge any information. So instead why not the new source? China. All it took was one query and the answers were there.
Links to All Parts of this Report
PART 1: Introduction (A billion dollars ― lots of zeros)
PART 2: Every Figure Tells a Story (Calculations and Result)
PART 3: Newest Member of the Premarin Family ― Duavee (Approved by FDA October 2013, originally submitted under the name Aprela)